The influence of antibody-containing fractions on the lethal and tumor-necrotizing actions of polysaccharides from Serratia marcescens (Bacillus prodigiosus).
نویسندگان
چکیده
Because of certain undesirable reactions, such as elevation in temperature and drop in blood pressure, observed in patients receiving tumor-necrotizing polysacchatides, it is important to investigate procedures which have potentialities for reducing the toxicity of the polysaccharides without interfeting with the tumor-necrotizing action. I t seemed advisable, therefore, to ascertain whether passive immunization with rabbit antisera toward the polysaccharides from Serratia marcescens would decrease either the lethal or the tumornecrotizing actions (or both) of these polysaccharides in mice. Shwartzman (5) found that certain mixtures of Bacil lus t yphosus filtrate, and antityphoid horse serum upon injection into mice with sarcoma 180 protected the mice against early death without diminishing the extent of hemorrhage and necrosis of the tumors. The preparation of antisera toward the polysaccharides has been discussed in the preceding paper (2). In the first series of tests to be described, normal mice were immunized passively with the y-globulin fraction from antisera toward the polysaccharides prior to the injection of lethal doses of the polysacchatides. In the second series of experiments, mice bearing sarcoma 37 were immunized passively with these y-globulin fractions and then injected with relatively large tumornecrotizing doses of polysaccharides.
منابع مشابه
Comparative studies of the immunological, toxic and tumor-necrotizing properties of polysaccharides from Serratia marcescens (Bacillus prodigiosus).
These studies are concerned with the immunological, toxic and tumor-necrotizing properties of purified polysaccharide-lipid complexes obtained by the methods of Shear and his associates (8, 14) from filtrates of cultures of Serratia marcescens (Bacillus t~rodigiosus). The project was undertaken as part of a joint institutional program with the Chemotherapy Section of the National Cancer Institu...
متن کاملThe biosynthesis of prodigiosin, the tripyrrylmethene pigment from Bacillus prodigiosus (Serratia marcescens).
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عنوان ژورنال:
- Cancer research
دوره 8 7 شماره
صفحات -
تاریخ انتشار 1948